This contributed volume collects innovative papers by scholars from Europe, India, and the USA to investigate how spirituality can contribute to renewing business in response to the challenges of the Anthropocene era. These challenges include climate change, biodiversity loss, ecosystems collapse, growing inequality, wellbeing deficiencies, and social unrest. Using insights from Christianity, Hinduism, Buddhism, and Existential Humanism the book explores the spiritual aspects of the present ecological, economic, social and ethical crises, materialist worldviews in the Anthropocene and their relation to crises. Further, it reinterprets personalism for embracing ecological values, presents working models of spiritually-based sustainability practices in business, and discusses the integration of spirituality into business education to foster a greater understanding of our interconnectedness with the planet and with each other. Part of the Palgrave Studies in Sustainable Business in Association with Future Earth book series, this interdisciplinary work will be of great interest to scholars and students of sustainability, spirituality in business, leadership, and many other fields.